The Green Chemistry Group was founded in 2007 as a nonprofit organization dedicated to the advancement of SFC and environmentally sustainable chemical research and development worldwide.
A Decade of SFC Conferences
We organized the first International Conference on Packed Column SFC, held a decade ago in Pittsburgh, PA
Since then, we have hosted an annual SFC conference, alternating between the U.S. and Europe, and starting in 2015 added Asia too. Each conference now attracts approximately 200 scientists, from around the globe and spanning many industries, who use – or are considering – SFC as a green technology.
These scientific conferences feature:
- keynote addresses
- oral and poster presentations
- an exhibition of the latest technologies and applications in supercritical fluid chromatography (SFC) and supercritical fluid extraction (SFE)
In addition to our annual SFC conferences, the Green Chemistry Group offers SFC short courses and funds travel scholarships so select academic researchers may present their research at various scientific conferences.
The Green Chemistry Group’s board of directors is a volunteer group of dedicated academics, industrial scientists, and leaders from sponsor organizations – those providing the equipment platforms, consumable solutions, and consulting services essential to SFC.
Our mission is to advance the use of SFC and build maximum interaction within the growing SFC community by hosting annual, international conferences.
Nick Mitchell, director of sales and marketing of Phenomenex products in China, was named president of the Green Chemistry Group’s board in 2016. He has been on the board since GCG’s inception in 2007, serving successive terms as secretary, treasurer, and president.
Nick began his career at the former Wyeth Research, before joining Phenomenex in 1999 as a member of its outside sales team. He moved into business development, where he played a role in developing relationships with other companies in the Life Sciences arena to provide collaborative solutions to the pharma and biotech communities. Nick eventually took on the responsibility of developing the large-scale prep column and bulk media business in collaboration with companies that manufacture Dynamic Axial Compression equipment. Over the last five years, Nick has lived in Asia (India and China) and is overseeing various aspects of the company’s developments in these regions.
“I would say I’m passionate about developing green manufacturing processes; whether it be via extraction, separation, or other means,” Nick said. “I’m also passionate about macro-economics, especially within emerging economies, where these green processes have an opportunity to provide the greatest impact.”
Frank Riley, senior principal scientist at Pfizer, began his pharmaceutical career in 1993 with Warner-Lambert/Parke-Davis in the Analytical Method Development group where he supported early-to-late-stage development activities. From that time, Frank traversed the drug development space taking on various roles as a manufacturing team-lead to building and then leading a separation and purification sciences group supporting a Drug Discovery organization. In 2007, Frank moved to Groton and joined the Structure Elucidation Group where he currently leads the isolation/purification component of SEG along with his team providing technology development and separation sciences support. In addition to these functions, Frank and his team partner with industrial and academic collaborators to advance Supercritical Fluid Chromatography applications and technology advancement.
Ray McClain, associate principal scientist at Merck, started at Merck in the late 1990s, after working at Lockheed-Martin where he performed trace metals analysis using ICP. At Merck, he has worked in Quality, supported vaccines, managed the separations lab in Discovery Chemistry, and today is involved in Analytical Sciences. He earned his bachelor’s degree, ACS-certified, in Chemistry from Elizabethtown College.
“I enjoy SFC and, shy of being intimidated when the outlet of first column started ‘hissing,’ find it a very powerful and fun technique,” he says.
Francis Mannerino, technical account manager and preparative separation specialist at SiliCycle, started his career 20+ years ago as an HPLC column packer for Regis Technologies. He subsequently held multiple positions there, including Director of Chromatography and Director of Preparative Separations. While at Regis, Francis and his team designed and built the world’s first contract lab that performed preparative SFC separation services under GMP. For the past 5+ years, he has been with Quebec-based SiliCycle, Inc.
“While I’m not in the lab anymore, I’m still dedicated to the growth and regulatory advancement of supercritical fluid chromatography,” said Fran.
J. David Pinkston, Principal Scientist in Kellogg’s Global Chemistry organization and Green Chemistry Group board member since 2007, has been involved in the analytical uses of supercritical fluids for over 30 years. He has used SFC, SFE, and related techniques to study personal care products, surfactants, polymers, pharmaceuticals, and foods, among other things. Most recently, his interests have focused on flavor/aroma chemistry, trace-level contaminants, and oil/fat/lipid chemistry.
David received his Ph.D. from Michigan State University, working in separations and mass spectrometry under the direction of J. Throck Watson and John Allison.
He was chair of the ACS’s Division of Analytical Chemistry in 2002 – 2003, was the Division’s program chair for the Fall 2002 and Spring 2003 National ACS Meetings, and has served on the executive committee of the Subdivision of Chromatography and Separations Chemistry. David has authored or co-authored over 55 publications, and presented over 130 lectures, the majority of which are in the areas of SFC and SFC/MS. He has taught various versions of the SFC short course since the early 1990s.
“I’m an advocate of the use of supercritical fluids not only because of their environmental and cost-saving advantages, but because they provide technical advantages not easily obtained using conventional methods,” David said.
Eric Seest, a research scientist at Eli Lilly, is a team leader in Eli Lilly’s Discovery Chemistry Analytical Chemistry operation. He started at Lilly in 2003 in its large-scale purification operation, later leading the group in the application of Steady State Recycle HPLC and SFC to kg scale chiral separations. Prior to that, in 1987, Eric worked in the Natural Products Isolation and Characterization Discovery research group at Upjohn Co, where he was immersed in chromatography and separation science, including such highlights as developing lab-based analytical and preparative chiral HPLC. He did graduate work in Chemistry at the University of California, Irvine, and earned a bachelor’s degree in Chemistry from Bradley University and worked part time as a research associate at the USDA-NRRC. “I cut my teeth into SFC in 1997; using equipment that helped revolutionize the packed column SFC approach to pharmaceutical molecule chromatographic separations,” he said. “As a member of the Green Chemistry Board I enjoy being part of the effort to spread the good word of SFC to the masses.”
Larry Miller, principal scientist in the Discovery Attribute Sciences group at Amgen, has more than 30 years of experience performing small molecule achiral and chiral purifications at the mg to multi-kg scale. At Amgen, where he has worked for 13 years, Larry manages a center of excellence at two R&D sites that are responsible for all small-molecule purification support for the company’s discovery and development departments. Previously, he spent 20 years at Searle/Pharmacia.
Larry has more than 30 peer reviewed publications and over 35 presentations at scientific meetings; he has served as co-instructor for SFC short courses in the US, Europe and Asia. From 2011 to 2016 he served as president of the Green Chemistry Group. He earned his master’s in chemistry from Roosevelt University and a bachelor’s in chemistry and biochemistry from the University of Illinois at Urbana-Champagne.
“My early purification experience was using HPLC, but over the past 15 years I’ve moved heavily into SFC and now act as an ambassador for the expansion of SFC into new industries and areas of separation science,” Larry said.
Larry T. Taylor is Emeritus Professor of Chemistry at Virginia Tech and President of Applied Analytical, Inc. He has been a member of the editorial boards for the Journal of Chromatographic Science, Chromatographia, and the Journal of Supercritical Fluids. He was a member of the organizing committee for the 4th through the 10th International Symposia on SFC/SFE during the 1980s. More recently he has served as the co-chair of the Scientific Committee for Green Chemistry Group’s SFC 2008 (Zurich), SFC 2009 (Philadelphia), SFC 2010 (Stockholm), SFC 2011 (New York City), SFC 2012 (Brussels), SFC 2013 (Boston), SFC 2014 (Basal), and SFC 2015 (Philadelphia). Larry is the author or co-author of approximately 400 peer reviewed publications, one book entitled “Analytical Supercritical Fluid Extraction”, and 12 patents. He presently serves as co-teacher of short courses addressed to SFC and SFE. Industrial partnerships have included: Waters Corp., Pfizer, Eli Lilly, Princeton Chromatography, ES Industries, Amgen, Applied Separations, Procter & Gamble, Merck, Wythe, and Abbott Labs.
Supercritical fluids offer a convenient means to achieve solvating properties that have gas- and liquid- like characteristics without actually changing chemical structure.
By proper control of pressure and temperature, one can access a significant range of physicochemical properties without ever passing through a phase boundary. That is, a supercritical fluid is a continuously adjustable solvent.